New research reveals that subtle chemical changes to proteins after synthesis play a critical role in determining ...

Inside every human cell, proteins are constantly being tagged with small chemical modifications after they're produced. Known ...

Protein modifications matter: Scripps Research showed post-translational modifications can dictate whether proteins bind to drugs, potentially guiding more selective therapy design. Hidden ...

Objectives Smoking is recognised as one of the strongest environmental risk factors for the development of rheumatoid ...

Protein AMPylation represents a specialised post‐translational modification (PTM) in which an adenosine monophosphate (AMP) moiety is covalently attached to specific amino acid residues on target ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

An AI model that reveals how protein modifications link genetic mutations to disease has been developed. Researchers at Baylor College of Medicine (TX, USA) have developed an AI model that reveals how ...

LA JOLLA, CA—Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit. In our cells, ...

Depression is a debilitating mental health disorder that remains a substantial global health challenge. Despite the availability of various antidepressants, treatment outcomes often face limited ...

One of the first things that students learn when they enter a biology class is the central dogma: DNA → messenger RNA → proteins. Only about 3% of the human genome directly codes for proteins, which ...