New research reveals that subtle chemical changes to proteins after synthesis play a critical role in determining ...

Inside every human cell, proteins are constantly being tagged with small chemical modifications after they're produced. Known ...

Protein modifications matter: Scripps Research showed post-translational modifications can dictate whether proteins bind to drugs, potentially guiding more selective therapy design. Hidden ...

One of the main goals of proteomics is to unravel the many modifications important for biological activity. Post-translational modifications (PTMs) extend the range of protein function by attaching it ...

Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.

The focus of vertebrate studies has mainly been on canonical phosphorylation, but research indicates that phosphorylation of other non-canonical amino acids also regulates integral aspects of cell ...

Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide. Additionally, about one-fourth of the world's population carries Mycobacterium ...

Objectives Smoking is recognised as one of the strongest environmental risk factors for the development of rheumatoid ...

As the “Method of the Year 2024”, spatial proteomics (SP) enables in situ characterization of protein localization, abundance, and interactions across subcellular to tissue scales, surpassing ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...